Sunday, December 16, 2007
Human genetics describes the study of inheritance as it occurs in human beings. This article describes only basic features of human genetics; for the genetics of disorders please see: Medical genetics.
Chromosomes
Estimates of the number of genes humans have has been possible since DNA sequencing was first introduced. Estimates however have varied wildly, though the present best guess is 20,000-25,000, estimates of up to 40,000 have been in the past.
Number of genes
In addition to nuclear DNA, humans (like almost all eukaryotes) have mitochondrial DNA. Mitochondria, the "power houses" of a cell, have their own DNA because they are descended from a proteobacterium that merged with eukaryotic cells over 2 billion years ago; an assertion known as the endosymbiotic hypothesis. Mitochondria are inherited from one's mother, and its DNA is frequently used to trace maternal lines of descent (see mitochondrial Eve).
Mitochondrial DNA
Genes have both minor and major effects on human characteristics. Human genes have become prominent in the nature versus nurture debate.
Genes and human characteristics
Genes have a strong influence on human behavior. IQ is largely heritable. However, this has been questioned. The stance that humans inherit substantial behavioral characteristics is called psychological nativism, compared to the stance that human behavior and culture are virtually entirely constructed (tabula rasa).
In the early 20th century, eugenics was policy in parts of the United States and Europe. The goal was to reduce or eliminate people whose genes were considered inferior. One form of eugenics was compulsory sterilization of people deemed mentally unfit. Hitler's eugenics programs turned social consciousness against the practice, and psychological nativism became associated with racism and sexism.
Genes and behavior
The biggest genetic difference among healthy humans is in gender. Scientists debate the extent to which genes and culture affect gender roles. The case of David Reimer was once a case in point for the tabula rasa camp, though recently that same case has become evidence for a strong genetic component to gender identity.
Genes and gender
Most genetic diversity occurs within races rather than between them. Common concepts of racial categories do not accurately match genetic characteristics.
Genes and race
Evolutionary psychology explains many human behaviors as more or less moderated by genes that evolved in the hunter-gatherer stage of human cultural development. See for example Stockholm syndrome.
Human traits with simple inheritance patterns
Human mitochondrial DNA (mtDNA) haplogroups
Human Y-chromosome DNA (Y-DNA) haplogroups
Human evolutionary genetics
Human genome
Genetic genealogy
Genealogical DNA test
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